2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
    Neuronal Signaling
  4. Calcium Channel

Calcium Channel

Ca2+ channels; Ca channels

Calcium Channel

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Calcium channel is an ion channel which displays selective permeability to calcium ions. It is sometimes synonymous as voltage-dependent calcium channel, although there are also ligand-gated calcium channels. Voltage-gated calcium (CaV) channels catalyse rapid, highly selective influx of Ca2+ into cells despite a 70-fold higher extracellular concentration of Na+. Some calcium channel blockers have the added benefit of slowing your heart rate, which can further reduce blood pressure, relieve chest pain (angina) and control an irregular heartbeat.

Calcium Channel Isoform Specific Products:

Calcium Channel Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P0189A
    ω-Conotoxin GVIA TFA
    		Inhibitor 99.33%
    ω-Conotoxin GVIA TFA is an inhibitor of the N-type Ca2+ channel.
    ω-Conotoxin GVIA TFA
  • HY-121119
    MRS 1523
    		Inhibitor 99.93%
    MRS 1523 is a potent and selective adenosine A3 receptor antagonist with Ki values of 18.9 nM and 113 nM for human and rat A3 receptors, respectively. In rat this corresponds to selectivities of 140- and 18-fold vs A1 and A2A receptors, respectively. MRS 1523 can exert antihyperalgesic effect through N-type Ca channel block and action potential inhibition in isolated rat dorsal root ganglion (DRG) neurons.
    MRS 1523
  • HY-B0984
    Fendiline hydrochloride
    		Inhibitor 99.80%
    Fendiline hydrochloride is a nonselective calcium channel blocker.
    Fendiline hydrochloride
  • HY-17436
    Clevidipine
    		Antagonist 99.88%
    Clevidipine is a short-acting dihydropyridine calcium channel antagonist (IC50= 7.1 nM, V(H) = -40 mV ).
    Clevidipine
  • HY-B0358
    Flunarizine
    		Inhibitor 99.93%
    Flunarizine is a potent dual Na+/Ca2+ channel (T-type) blocker. Flunarizine is a D2 dopamine receptor antagonist. Flunarizine shows anticonvulsive and antimigraine activity, and peripheral vasodilator effects.
    Flunarizine
  • HY-B0282S
    Acetylcholine-d4 chloride
    		Activator 99.07%
    Acetylcholine-d4 (chloride) is the deuterium labeled Acetylcholine chloride. Acetylcholine chloride (ACh chloride), a neurotransmitter, is a potent cholinergic agonist. Acetylcholine chloride is a modulator of the activity of dopaminergic (DAergic) neurons through the stimulation of nicotinic acetylcholine receptors (nAChRs)[1][2]. Acetylcholine chloride inhibits p53 mutant peptide aggregation in vitro[5].
    Acetylcholine-d<sub>4</sub> chloride
  • HY-W074890
    Palmitoylglycine
    		Modulator 99.74%
    Palmitoylglycine (N-palmitoyl glycine), an endogenous lipid that acts as a modulator of calcium influx and nitric oxide (NO) production in sensory neurons.
    Palmitoylglycine
  • HY-15125
    (R)-(+)-Bay-K-8644
    		Inhibitor
    (R)-(+)-Bay-K-8644 is a calcium channel inhibitor. (R)-(+)-Bay-K-8644 inhibits Ba2+ currents (IBa) (IC50=975 nM).
    (R)-(+)-Bay-K-8644
  • HY-11013
    ZSET1446
    		Activator 98.01%
    ZSET1446 is a novel cognitive enhancer that significantly improves learning deficits in various types of Alzheimer disease (AD) models.
    ZSET1446
  • HY-N0607
    Ginsenoside Ro
    		Antagonist 99.81%
    Ginsenoside Ro (Polysciasaponin P3; Chikusetsusaponin 5; Chikusetsusaponin V) exhibits a Ca2+-antagonistic antiplatelet effect with an IC50 of 155 ?μM. Ginsenoside Ro reduces the production of TXA2 more than it reduces the activities of COX-1 and TXAS.
    Ginsenoside Ro
  • HY-124873
    SERCA2a activator 1
    		Activator 99.54%
    SERCA2a activator 1 (Compound A) is a sarco/endoplasmic reticulum Ca2+-dependent ATPase 2a (SERCA2a) activator. SERCA2a activator 1 attenuates phospholamban inhibition and enhances the systolic and diastolic functions of the heart. SERCA2a activator 1 can be used for heart failure.
    SERCA2a activator 1
  • HY-B0768A
    Lomerizine dihydrochloride
    		Antagonist 99.84%
    Lomerizine dihydrochloride is an antagonist of L- and T-type voltagegated calcium channels.
    Lomerizine dihydrochloride
  • HY-N0601
    Ginsenoside Rf
    		Inhibitor 99.48%
    Ginsenoside Rf is a trace component of ginseng root. Ginsenoside Rf inhibits N-type Ca2+ channel.
    Ginsenoside Rf
  • HY-B0549A
    Flavoxate hydrochloride
    		Antagonist 99.85%
    Flavoxate hydrochloride is a potent and competitive phosphodiesterase (PDE) inhibitor. Flavoxate hydrochloride is an antispasmodic agent and muscarinic mAChR antagonist. Flavoxate hydrochloride shows moderate calcium antagonistic activity and local anesthetic effect. Flavoxate hydrochloride can be used for the research of overactive bladder (OAB) and lower urinary tract infections.
    Flavoxate hydrochloride
  • HY-14657
    Dantrolene sodium
    		Inhibitor ≥98.0%
    Dantrolene sodium salt is a calcium channel protein inhibitor that inhibits the release of calcium ions from the sarcoplasm. Dantrolene sodium salt hydrate is a skeletal muscle relaxant.
    Dantrolene sodium
  • HY-12650
    Mirogabalin
    		Inhibitor 99.31%
    Mirogabalin (DS-5565) is a novel, preferentially selective α2δ-1 ligand characterized by high potency and selectivity to the α2δ-1 subunit of voltage-sensitive calcium channel complexes in the CNS.
    Mirogabalin
  • HY-P0062B
    Ziconotide acetate
    		Antagonist 99.58%
    Ziconotide acetate (SNX-111 acetate), a peptide, is a potent and selective block of N-type calcium channels antagonist. Ziconotide acetate reduces synaptic transmission, and can be used for chronic pain research.
    Ziconotide acetate
  • HY-110237
    BX430
    		Inhibitor 99.83%
    BX430 is a potent and selective noncompetitive allosteric human P2X4 receptor channels antagonist with an IC50 of 0.54 μM. BX430 has species specificity. BX430 is used for chronic pain and cardiovascular disease.
    BX430
  • HY-101096
    Suvecaltamide
    		Inhibitor 99.96%
    Suvecaltamide (MK-8998; compound 33) is a potent and selective inhibitor of the T-type calcium channel.
    Suvecaltamide
  • HY-B1655
    Fluspirilene
    		Antagonist 99.66%
    Fluspirilene is a non-competitive antagonist of L-type calcium channels with an IC50 of 0.03 μM. Fluspirileneis a long-acting injectable depot antipsychotic agent used for schizophrenia.
    Fluspirilene
Cat. No. Product Name / Synonyms Application Reactivity
Calcium Channel Isoform Comparison

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